A teal Lira Clinical gift box tied with a white satin ribbon, shown on a clean white background with a soft reflection.

Two skincare bottles from Lira Clinical on a white background: a frosted pump bottle labeled Regen PDRN+ Crème and a white dropper bottle labeled Regen PDRN+ Serum with a silver collar.

Lira London gift set featuring two keychains on display cards and a white drawstring bag, with text noting one surprise keychain is included.

REGEN Holiday Gift Box 2026 Limited Time

$220.00

Shipping calculated at checkout.

Orders over $75 ship free in the US.

Available for a limited time

This luxurious limited-edition gift set features a full-size REGEN Serum and Crème, along with an exclusive array of Lira Clinical gifts including a tote bag, cosmetic case, and keychain/bag charm* — elegantly presented in a premium custom box that’s ready for gifting your loved ones, or treating yourself.

Rebuild From Within Like Never Before. REGEN PDRN+ Serum harnesses a synergistic blend of three potent actives: PDRN, Copper Tripeptide-1, and Wild Salmon Stem Cell-CM—Lira Clinical's pioneering introduction to the clinical skincare market. This advanced formulation delivers 4x more regenerative power than PDRN alone, working to calm inflammation, repair compromised skin barriers, and stimulate deep cellular renewal. The result is visibly transformed skin: enhanced hydration that lasts, restored firmness, and a clinically brightened complexion that reflects true skin health. Each application targets the root causes of aging and sensitivity, supporting your skin's natural regenerative capacity for a refined, luminous finish. Ideal for those seeking professional-grade efficacy with spa-inspired elegance. Experience the difference when science meets nature in a single, luxurious serum.

REGEN PDRN+ Crème represents a breakthrough in volumizing skincare technology, engineered to address the visible signs of loss of elasticity and diminished radiance. This luxurious crème harnesses Lira's proprietary regenerative ingredient complex to stimulate the skin's natural renewal processes, promoting a visibly fuller, firmer complexion. Formulated with advanced peptide and hydration technology, REGEN PDRN+ Crème works to restore volumetric density while strengthening the skin's structural integrity. The result is a refined, lifted appearance with enhanced firmness and a luminous glow that speaks to deeply nourished, revitalized skin. Ideal for those seeking clinical-grade results with a spa-inspired sensorial experience, this crème delivers sustained hydration and visible brightening benefits with each application. The sophisticated formula absorbs seamlessly, leaving skin feeling supple, resilient, and noticeably transformed.

How to use

Upon cleansed skin, massage 1-2 drops into the skin followed by your desired hydrator or SPF. If using PRO Lite Serum or PRO Brite-Plus Serum, apply after your melanin management serum.

Then massage two pumps into clean skin, allowing product to fully absorb. Follow with appropriate Lira Clinical® serum, moisturizer, and/or SPF product.

Ingredients

REGEN PDRN Serum
Science Ingredients:
Wild Salmon Stem Cell Conditioned
Media (aka MCC):
Clean, sustainable, bio-tech marine cellular
complexes (MCC) with 4x more regenerative
power than PDRN alone. Exosomes, growth
factors, and stem cells in the MCC increases
collagen repair and decreases inflammation.

Copper Tripeptide-1:
Improves skin firmness and elasticity,
skin appears pumper and youthful with
old skin cells behaving like younger ones.
Antioxidant and anti-inflammatory effects;
initiates a speedy skin recovery and repair.

Oligopeptide-1:
Epidermal growth factor (EGF), epithelial
regeneration and accelerates skin
regeneration, cytoprotective activities
promoting health barrier activities, slows the
thinning of the SC, regenerates youthful cell
proliferation.

Argireline™ & Syn®-ake:
Neurotransmitter blocker reduces muscle
contraction frequency by up to 82%;
Relaxes facial muscles but allows for
natural expression.

Palmitoyl Tripeptide-1 &
Tetrapeptide-7:
Assists in collagen synthesis and skin repair,
essential for compromied skin such as
rosacea and eczema, encoraging healthy
cell function.
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Nature Ingredients
PDRN (Polydeoxyribonucleotides,
Sodium DNA):
Biocompatible salmon DNA, restores
the extracellular matrix (ECM) for
comprehensive tissue repair, moderates the
inflammatory response, reducing redness,
and prevents sporadic hyperpigmentation.

Curcuma Longa (Turmeric) Extract:
Anti-inflammatory and skin brightener,
reduces redness especially from acne; skin
repair and restoration.

Corallina Officinalis Extract:
Mineral-rich red algae, (calcium &
magnesium) aiding in hydration and
strengthening skin’s barrier.

Full ingredients:
WATER (AQUA), WILD SALMON STEM CELL CONDITIONED MEDIA (AKA MCC), GLYCERIN, NIACINAMIDE, PEG-8/SMDI COPOLYMER, SODIUM DNA, BUTYLENE GLYCOL, CARBOMER, MOMORDICA CHARANTIA FRUIT EXTRACT, ZINGIBER OFFICINALE (GINGER) ROOT EXTRACT, SODIUM HYALURONATE, ETHYLHEXYLGLYCERIN, SODIUM HYDROXYIDE, MANNITOL, CITRUS PARADISI (GRAPEFRUIT) PEEL OIL, DMAE BITARTRATE, MALUS DOMESTICA FRUIT CELL CULTURE EXTRACT, PHOSPHATIDYLCHOLINE, CAMELLIA SINENSIS LEAF EXTRACT, MELIA AZADIRACHTA FLOWER EXTRACT, PHOSPHOLIPIDS, SODIUM PHYTATE, MELIA AZADIRACHTA LEAF EXTRACT, LACTOBACILLUS FERMENT, CORALLINA OFFICINALIS EXTRACT, SODIUM LACTATE, 1,2-HEXANEDIOL, HYALURONIC ACID, LEONTOPODIUM ALPINUM MERISTEM CELL CULTURE, POTASSIUM SORBATE, SODIUM BENZOATE, COCCINIA INDICA FRUIT EXTRACT, POLYSORBATE 20, SPIRAEA ULMARIA FLOWER EXTRACT, XANTHAN GUM, CETYL ALCOHOL, DECYL GLUCOSIDE, TAURINE, CENTELLA ASIATICA FLOWER/LEAF/STEM EXTRACT, ISOMALT, ALOE BARBADENSIS FLOWER EXTRACT, SOLANUM MELONGENA (EGGPLANT) FRUIT EXTRACT, CITRIC ACID, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE, CRITHMUM MATITIMUM EXTRACT, CAPRYLYL GLYCOL, COFFEE ARABICA (COFFEE) SEED EXTRACT, SODIUM CHLORIDE, CURCUMA LONGA (TUMERIC) ROOT EXTRACT, OCIMUM BASILICUM (BASIL) FLOWER/LEAF EXTRACT, OCIMUM SANCTUM LEAF EXTRACT, LECITHIN, BIA(TRIPEPTIDE-1) COPPER ACETATE, ACETYL HEXAPEPTIDE-8, PALMITOYL TRIPEPTIDE-1, PALMITOYL TETRAPEPTIDE-7, ARGININE, LEUCINE, LYSINE, VALINE, RHODODENDRON FERRUGINEUM LEAF CELL CULTURE EXTRACT, LACTIC ACID, DIPOTASSIUM PHOSPHATE, OLIGOPEPTIDE-1, PHENOXYETHANOL, POTASSIUM PHOSPHATE, CITRUS SINENSIS

REGEN PDRN Creme
Science Ingredients
Wild Salmon Stem Cell Conditioned Media (aka MCC):
Clean, sustainable, biomimetic marine cellular complexes (MCC)
with 4x more regenerative power than PDRN alone. Exosomes in the
MCC increases collagen repair and decrease inflammation

Adipofill’in™ (L-Ornithine):
Activates adipogenesis: produces fat cells, increases triglyceride
storage inflating adipocytes, activates lipogenesis (fatty acid
synthesis), inhibits lipolysis, creates a lipofilling-like effect on the skin non-invasively.

Oligopeptide-1:
Epidermal growth factor (EGF), epithelial regeneration and
accelerates skin regeneration, cytoprotective activities promoting
health barrier activities, slows the thinning of the SC, regenerates
youthful cell proliferation.

Copper Tripeptide-1:
Improves skin firmness and elasticity, skin appears pumper and
youthful with old skin cells behaving like younger ones. Antioxidant
and anti-inflammatory effects; initiates a speedy skin recovery
and repair.

Nicotiana Benthamiana Hexapeptide-40 shPolypeptide-47:
Fusion peptide: derived from the tobacco plant genetically
transformed to produce this unique signaling peptide. Enhances
skin’s healthy barrier activity, maintains healthy function in skin,
beneficial for compromised skin.

Chromabright™ (Dimethylmethoxy Chromanyl Palmitate):
Inhibits melanogenesis, evens skin tone, brightens, and protects
against UV environmental aging.
Icon
Nature Ingredients
PDRN (Polydeoxyribonucleotides, Sodium DNA):
Biocompatible salmon DNA, restores the extracellular matrix
(ECM) for comprehensive tissue repair, moderates the
inflammatory response reducing redness, and prevents sporadic
hyperpigmentation.

Kangaroo Paw Flower Extract (Anigozanthos Flavidus
Extract) - GLYCOPROTEIN:
TENASCIN-X: rebuilds the architecture of the dermis, regulates
spacing between collagen fibrils and elastin fibers, provides
structural support to the extracellular matrix (ECM), improves the
organization and biomechanical properties of the ECM.

Macrocystis Pyrifera (Kelp) Extract:
Skin tightener; kelp known as the Sequoia of the Sea, immediate
smoothing effect to skin, natural polysaccharide, prompting cellular
function and retaining moisture.

Full Ingredients:
WATER (AQUA), WILD SALMON STEM CELL CONDITIONED MEDIA, GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, ISODECYL NEOPENTANOATE, DIMETHICONE, PROPANEDIOL, COCONUT ALKANES, BUTYLENE GLYCOL, BUTYROSPERMUM PARKII (SHEA) NUT EXTRACT, CETEARYL ALCOHOL, STEARIC ACID, GLYCERYL STEARATE, PEG-100 STEARATE, MANGIFERA INDICA (MANGO) SEED BUTTER, PPG-12/SMDI COPOLYMER, PHENOXYETHANOL, C10 30 ALKYL ACRYLATE CROSSPOLYMER, DIMETHICONE CROSSPOLYMER, TRIETHYL CITRATE, CAPRYLYL GLYCOL, ORNITHINE, COCO-CAPRYLATE/CAPRATE, PHOSPHOLIPIDS, MACROCYSTIS PYRIFERA (KELP) EXTRACT, THYLHEXYLGLYCERIN, HEXYLENE GLYCOL, SODIUM HYDROXIDE, MANNITOL, DIMETHYLMETHOXY CHROMANYL PALMITATE, SODIUM DNA, PHOSPHATIDYLCHOLINE, GLYCOLIPIDS, PVP, COPPER TRIPEPTIDE-1, PENTYLENE GLYCOL, HYALURONIC ACID, HYDROLYZED VEGETABLE PROTEIN, TOCOPHEROL, ANIGOZANTHOS FLAVIDUS EXTRACT, SODIUM HYALURONATE, POTASSIUM SORBATE, CETYL ALCOHOL, SODIUM BENZOATE, GAMMA-UNDECALACTONE, RASPBERRY KETONE, DECYL GLUCOSIDE, LEVULINIC ACID, P-ANISIC ACID, SILANETRIOL, XANTHAN GUM, ETHYL 2-METHYLBUTYRATE, HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL, SODIUM CHLORIDE, BIOTIN, NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-47, DIPOTASSIUM PHOSPHATE, OLIGOPEPTIDE-1, POTASSIUM PHOSPHATE, CITRUS MEDICA LIMONUM/LEMON OIL, LINALOOL, VANILLIN, LIMONENE.

Processing Time

All orders are processed within 2–5 business days. Orders are not processed or shipped on weekends or holidays. If we are experiencing a high volume of orders, processing may be delayed by a few days. We'll notify you by email if there is a significant delay.

Shipping Rates & Delivery

We offer free shipping on Order $75+. Shipping rates are calculated at checkout based on your location and selected shipping method. Delivery times vary depending on your location and the carrier.

Domestic Orders (U.S.) Standard shipping typically arrives within 5–7 business days after processing.

International Orders: We ship internationally, excluding the entire Lira Clinical line. Please note that international orders may be subject to customs fees, duties, or taxes imposed by your country.

These charges are the responsibility of the customer and are not included in our shipping rates.

Order Tracking:

Once your order has shipped, you will receive a confirmation email with a tracking number. Please allow 24–48 hours for tracking information to update.

Lost or Damaged Packages:

If your order arrives damaged or is lost in transit, please contact us at jessica@earthesthetics.com so we can resolve the issue promptly.

Questions? Reach out to us anytime at jessica@earthesthetics.com

What’s your return/exchange policy on skincare products?

30-day return policy with conditions, exceptions, and exchange info. The item mustn’t be used within 30 days to receive a full refund. Exchanges accepted upon evaluation. Additional shipping costs may occur.

Do you offer product recommendations or skin quizzes for online shoppers who can’t get an in-person consult?

TBD

How do I know which products are right for my skin type?

Earth Esthetics has a very helpful guide in the menu section to search for products based on your skin condition and type. We also offer virtual skin consultations if you need further assistance. Schedule Services

Are your products cruelty-free / clean / fragrance-free

Yes — all the brands we carry (Lira Clinical, HOP+, AO Medical USA, Le Mieux) are cruelty-free. Many formulas are also fragrance-free, though this varies by product, so check individual product labels for specifics.

Do you have a loyalty rewards program?

Yes, we do! Once you become a member, you automatically receive $15/150 points to use towards your first purchase.

There are also multiple ways to earn free points. You earn one point per $1 you spend, and there are stipulations on how to use your points at checkout.

Some promos you may receive through email prohibits using points alongside another discount. Please visit the rewards page for more details. Rewards – Earth Esthetics

For all skin types

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Beauty in simplicity.

REGEN Holiday Gift Box 2026 Limited Time

How to use

Ingredients

Questions check here

Processing Time

Shipping Rates & Delivery

What’s your return/exchange policy on skincare products?

Do you offer product recommendations or skin quizzes for online shoppers who can’t get an in-person consult?

How do I know which products are right for my skin type?

Are your products cruelty-free / clean / fragrance-free

Do you have a loyalty rewards program?

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